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SIRT1 targets over 100 different proteins involved in metabolism, stress responses, and longevity pathways, including the tumor suppressor p53, the transcriptional coactivator PGC-1, and the DNA repair protein Ku70. Through deacetylation of PGC-1, SIRT1 promotes mitochondrial biogenesis and oxidative metabolism, while deacetylation of p53 reduces apoptotic responses to mild stress, promoting cellular survival and longevity

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Its impossible for me to not take the FDAs recommendations at heart with respect to safety and efficacy, said Kevin Zacharoff, a clinical assistant professor at Stony Brook University, who voted no to Emideltide

Current Pharmaceutical Design (2011) 6